Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.57 |
| ▸ | DRD3 | P35462 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.45 |
| ▸ | KHK | P50053 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27402876 | 0.92 | DRD2 (0.49) | DRD2DRD3MEN1NPC1RAB9A | |
| SCHEMBL11036692 | 0.86 | DRD2 (0.56) | DRD2DRD3MEN1NPC1RAB9A | |
| SCHEMBL7392292 | 0.84 | CACNA2D1 (0.46) | DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL7385931 | 0.84 | CACNA2D1 (0.45) | DRD2DRD3 | |
| SCHEMBL7394485 | 0.82 | S1PR1 (0.54) | DRD2 | |
| SCHEMBL7390623 | 0.82 | PRMT1 (0.44) | DRD2DRD3 | |
| SCHEMBL7390619 | 0.82 | PRMT1 (0.44) | DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL7393330 | 0.81 | PRMT1 (0.43) | DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL7395305 | 0.81 | S1PR1 (0.53) | DRD2 | |
| SCHEMBL7365851 | 0.81 | ACHE (0.62) | DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997028157-A1 | NOVEL PIPERIDINE DERIVATIVES 4-SUBSTITUTED BY AN IMIDAZOLIDIN-2-ON-1-YL-ETHYL, TETRAHYDROPYRIMIDIN-2-ON-1-YL-ETHYL AND 1,3-DIAZEPIN-2-ON-1-YL-ETHYL GROUP, AND USE THEREOF AS α2-ADRENERGIC RECEPTOR ANTAGONISTS | PIERRE FABRE MEDICAMENT (FR) | 1997-08-07 | — | — | WO | disclosed |