Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367345 | 0.85 | DDR1 (0.40) | MAPTALDH1A1L3MBTL1DDR1HPGD | |
| SCHEMBL7367629 | 0.77 | LMNA (0.50) | LMNAMAPTALDH1A1L3MBTL1KMT2A | |
| SCHEMBL7365533 | 0.75 | EPHX2 (0.42) | KMT2AMEN1DDR1RIPK1 | |
| SCHEMBL5162780 | 0.72 | LMNA (0.59) | LMNAMAPTALDH1A1L3MBTL1KMT2A | |
| SCHEMBL8684987 | 0.72 | CES1 (0.46) | ALDH1A1SMN1; SMN2RIPK1 | |
| SCHEMBL5969220 | 0.69 | LMNA (0.55) | LMNAMAPTALDH1A1L3MBTL1KMT2A | |
| SCHEMBL13402025 | 0.69 | CHRM2 (0.46) | LMNAMAPTALDH1A1L3MBTL1KMT2A | |
| SCHEMBL27815692 | 0.68 | KMT2A (0.49) | LMNAMAPTALDH1A1L3MBTL1KMT2A | |
| SCHEMBL8481321 | 0.66 | CHRM2 (0.50) | LMNAMAPTALDH1A1L3MBTL1KMT2A | |
| SCHEMBL3136680 | 0.66 | LMNA (0.48) | LMNAMAPTALDH1A1L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1259506-A1 | PYRAZINONE THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2002-11-27 | — | — | EP | disclosed |
| US-6387911-B1 | Pyrazinone thrombin inhibitors | MERCK & CO., INC. | 2002-05-14 | — | — | US | disclosed |
| WO-2001038323-A1 | PYRAZINONE THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2001-05-31 | — | — | WO | disclosed |