Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR1 | Q08345 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 6/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367627 | 0.85 | LMNA (0.43) | DDR1HPGDRIPK1ALDH1A1MAPT | |
| SCHEMBL7367349 | 0.78 | RIPK1 (0.47) | DDR1HPGDHSD17B10RIPK1ALDH1A1 | |
| SCHEMBL7366760 | 0.74 | DDR1 (0.40) | DDR1RIPK1 | |
| SCHEMBL7365533 | 0.72 | EPHX2 (0.42) | DDR1RIPK1 | |
| SCHEMBL25744603 | 0.71 | RIPK1 (0.42) | DDR1HPGDHSD17B10RXFP1RIPK1 | |
| SCHEMBL14507031 | 0.70 | GABRA1 (0.41) | DDR1HPGDHSD17B10RXFP1ALDH1A1 | |
| SCHEMBL8684987 | 0.70 | CES1 (0.46) | RIPK1ALDH1A1 | |
| SCHEMBL7362224 | 0.67 | APOBEC3G (0.61) | HPGDHSD17B10ALDH1A1MAPK1ALOX15 | |
| SCHEMBL7674655 | 0.67 | HPGD (0.39) | DDR1HPGDHSD17B10RXFP1ALDH1A1 | |
| SCHEMBL9988198 | 0.65 | APOBEC3G (0.37) | DDR1HPGDHSD17B10RXFP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1259506-A1 | PYRAZINONE THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2002-11-27 | — | — | EP | disclosed |
| US-6387911-B1 | Pyrazinone thrombin inhibitors | MERCK & CO., INC. | 2002-05-14 | — | — | US | disclosed |
| WO-2001038323-A1 | PYRAZINONE THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2001-05-31 | — | — | WO | disclosed |