Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.46 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367349 | 0.85 | RIPK1 (0.47) | LMNARIPK1DDR1ALDH1A1HPGD | |
| SCHEMBL5162780 | 0.80 | LMNA (0.59) | LMNACHRM2KMT2AGAAMAPT | |
| SCHEMBL5969220 | 0.80 | LMNA (0.55) | LMNACHRM2KMT2AGAAMAPT | |
| SCHEMBL2543341 | 0.80 | MTNR1A (0.40) | LMNARIPK1HPGDCDK5TAOK1 | |
| SCHEMBL7367009 | 0.79 | KMT2A (0.45) | RIPK1KMT2AGAAALDH1A1HPGD | |
| SCHEMBL7367627 | 0.77 | LMNA (0.43) | LMNACHRM2RIPK1DDR1KMT2A | |
| SCHEMBL2778215 | 0.77 | RIPK1 (0.46) | LMNARIPK1KMT2AGAAL3MBTL1 | |
| SCHEMBL8061739 | 0.77 | TSHR (0.52) | RIPK1KMT2AMAPTHSD17B10MEN1 | |
| SCHEMBL5644902 | 0.76 | ALDH1A1 (0.64) | LMNACHRM2DDR1KMT2AGAA | |
| SCHEMBL4477248 | 0.76 | KCNA5 (0.49) | LMNACHRM2KMT2AGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1259506-A1 | PYRAZINONE THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2002-11-27 | — | — | EP | disclosed |
| US-6387911-B1 | Pyrazinone thrombin inhibitors | MERCK & CO., INC. | 2002-05-14 | — | — | US | disclosed |
| WO-2001038323-A1 | PYRAZINONE THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2001-05-31 | — | — | WO | disclosed |