Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | HCK | P08631 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 1/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7365103 | 0.91 | GLO1 (0.46) | HTTSMN1; SMN2GLO1PIK3CDABL1 | |
| SCHEMBL7364301 | 0.83 | HTT (0.47) | HTTSMN1; SMN2GLO1KDM4ERAB9A | |
| SCHEMBL7368929 | 0.80 | TSHR (0.50) | HTTSMN1; SMN2GLO1KDM4ERAB9A | |
| SCHEMBL7370597 | 0.79 | L3MBTL1 (0.50) | SMN1; SMN2RAB9AALDH1A1L3MBTL1CYP2C19 | |
| SCHEMBL8693757 | 0.78 | PDE5A (0.51) | HTTSMN1; SMN2KDM4EMAPK1ALDH1A1 | |
| SCHEMBL7370208 | 0.77 | PDE4A (0.53) | HTTGLO1HPGDCYP1A2CYP2C19 | |
| SCHEMBL7365433 | 0.77 | ADORA1 (0.39) | HTTPIK3CDABL1EGFRHCK | |
| SCHEMBL7365746 | 0.77 | PDE4A (0.56) | HTTSMN1; SMN2GLO1KDRKDM4E | |
| SCHEMBL7359530 | 0.76 | PDE4A (0.48) | HTTSMN1; SMN2GLO1KDM4ERAB9A | |
| SCHEMBL7370601 | 0.76 | SRC (0.46) | PIK3CDABL1EGFRHCKSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |