Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20360930 | 0.71 | CRHBP (0.41) | MERTKALDH1A1HPGDSMN1; SMN2GAA | |
| SCHEMBL30503540 | 0.70 | CRHBP (0.59) | MERTKALDH1A1HPGDSMN1; SMN2GAA | |
| SCHEMBL19407671 | 0.70 | CRHBP (0.59) | MERTKALDH1A1HPGDSMN1; SMN2GAA | |
| SCHEMBL11607437 | 0.69 | POLB (0.47) | MERTKALDH1A1HPGDSMN1; SMN2GAA | |
| SCHEMBL20719247 | 0.69 | POLB (0.47) | MERTKALDH1A1HPGDSMN1; SMN2GAA | |
| SCHEMBL30437331 | 0.69 | TDP1 (0.66) | MERTKALDH1A1HPGDSMN1; SMN2GAA | |
| SCHEMBL6742273 | 0.69 | TDP1 (0.66) | MERTKALDH1A1HPGDSMN1; SMN2GAA | |
| SCHEMBL15647036 | 0.69 | RAB9A (0.49) | ALDH1A1HPGDSMN1; SMN2GAAL3MBTL1 | |
| SCHEMBL15195554 | 0.69 | CRHBP (0.42) | MERTKALDH1A1HPGDSMN1; SMN2GAA | |
| SCHEMBL19237079 | 0.68 | PDCD1LG2 (0.44) | MERTKALDH1A1HPGDSMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0613467-A1 | 2-PYRIDINOL DERIVATIVES AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1994-09-07 | — | — | EP | disclosed |
| WO-1993010093-A1 | 2-PYRIDINOL DERIVATIVES AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1993-05-27 | — | — | WO | disclosed |