Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 1/20 | 0.61 |
| ▸ | HTR1A | P08908 | 7/20 | 0.59 |
| ▸ | HTR2A | P28223 | 6/20 | 0.59 |
| ▸ | HTR2C | P28335 | 5/20 | 0.59 |
| ▸ | MPO | P05164 | 1/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.59 |
| ▸ | HTR1D | P28221 | 10/20 | 0.58 |
| ▸ | HTR1B | P28222 | 8/20 | 0.58 |
| ▸ | HTR7 | P34969 | 4/20 | 0.57 |
| ▸ | HTR5A | P47898 | 4/20 | 0.57 |
| ▸ | HTR6 | P50406 | 3/20 | 0.57 |
| ▸ | HTR2B | P41595 | 5/20 | 0.56 |
| ▸ | HTR1E | P28566 | 3/20 | 0.56 |
| ▸ | HTR1F | P30939 | 3/20 | 0.56 |
| ▸ | HTR3A | P46098 | 3/20 | 0.56 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.56 |
| ▸ | HTR3B | O95264 | 2/20 | 0.56 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.56 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.56 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2535250 | 0.99 | NQO2 (0.62) | NQO2HTR1AHTR2AHTR2CMPO | |
| SCHEMBL4723013 | 0.88 | PKM (0.67) | NQO2HTR1AHTR2AHTR2CMPO | |
| SCHEMBL8538163 | 0.85 | NQO2 (0.58) | NQO2HTR2ASLC6A4CYP2D6PKM | |
| SCHEMBL4777878 | 0.85 | NQO2 (0.53) | NQO2HTR1AHTR2AHTR2CMPO | |
| Dinitrophenylene SCHEMBL27321903 | 0.85 | HTR1A (0.51) | NQO2HTR1AHTR2AHTR2CMPO | |
| SCHEMBL11537110 | 0.83 | NQO2 (0.63) | NQO2HTR2APKMPKLRKMT2A | |
| SCHEMBL7008593 | 0.83 | NQO2 (0.66) | NQO2HTR2AMPOPKMPKLR | |
| SCHEMBL8122780 | 0.83 | NQO2 (0.49) | NQO2HTR1AHTR2AHTR2CMPO | |
| SCHEMBL3294986 | 0.82 | NQO2 (0.64) | NQO2HTR2ASLC6A4PKMPKLR | |
| SCHEMBL8629832 | 0.81 | NQO2 (0.67) | NQO2HTR2AHTR2CCYP2D6PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0666858-B1 | 5-ARYLINDOLE DERIVATIVES AND THEIR USE AS SEROTONIN (5-HT 1) AGONISTS | PFIZER (US) | 2001-06-13 | — | — | EP | disclosed |
| EP-1094064-A1 | 5-arylindolederivatives and their use as serotonin(5-ht1)agonists | PFIZER INC. (US) | 2001-04-25 | — | — | EP | disclosed |
| EP-0619805-B1 | 5-(HETERO- OR CARBOCYCLYLAMINO)-INDOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT1 AGONISTS | PFIZER (US) | 2000-03-15 | — | — | EP | disclosed |
| US-5886008-A | 5-arylindole derivatives | PFIZER INC. (US) | 1999-03-23 | — | — | US | disclosed |
| US-5639752-A | SEROTONIN AGONIST | PFIZER INC (US) | 1997-06-17 | — | — | US | disclosed |
| EP-0666858-A1 | 5-ARYLINDOLE DERIVATIVES AND THEIR USE AS SEROTONIN (5-HT 1?) AGONISTS | PFIZER INC. (US) | 1995-08-16 | — | — | EP | disclosed |
| EP-0619805-A1 | INDOLE DERIVATIVES | PFIZER HOSPITAL PRODUCTS, INC. (US) | 1994-10-19 | — | — | EP | disclosed |
| WO-1994010171-A1 | 5-ARYLINDOLE DERIVATIVES AND THEIR USE AS SEROTONIN (5-HT1) AGONISTS | PFIZER INC. (US) | 1994-05-11 | — | — | WO | disclosed |
| WO-1993011106-A1 | INDOLE DERIVATIVES | PFIZER, INC. (US) | 1993-06-10 | — | — | WO | disclosed |