Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7363973 | 0.91 | NPSR1 (0.50) | NPSR1ALDH1A1LMNAPDE4APDE4B | |
| SCHEMBL7361593 | 0.86 | NPSR1 (0.53) | NPSR1ALDH1A1LMNAPDE4APDE4B | |
| SCHEMBL7359895 | 0.83 | PDE4A (0.53) | NPSR1ALDH1A1LMNAPDE4APDE4B | |
| SCHEMBL7361659 | 0.82 | PDE4D (0.55) | NPSR1ALDH1A1LMNAPDE4APDE4B | |
| SCHEMBL7369583 | 0.81 | ALDH1A1 (0.56) | NPSR1ALDH1A1LMNAPDE4APDE4B | |
| SCHEMBL9172942 | 0.81 | NPSR1 (0.45) | NPSR1ALDH1A1LMNAPDE4APDE4B | |
| SCHEMBL7370126 | 0.79 | GRM5 (0.48) | NPSR1ALDH1A1LMNAPDE4APDE4B | |
| SCHEMBL7363896 | 0.79 | L3MBTL1 (0.58) | NPSR1ALDH1A1LMNAPDE4APDE4B | |
| SCHEMBL7365433 | 0.79 | ADORA1 (0.39) | NPSR1ALDH1A1LMNAPDE4APDE4B | |
| SCHEMBL7364120 | 0.79 | TBXAS1 (0.50) | NPSR1ALDH1A1PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |