Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11931998 | 0.86 | HRH3 (0.39) | KDM4EPOLBSIGMAR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7383331 | 0.80 | KDM4E (0.40) | KDM4EPOLBSIGMAR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL21023408 | 0.76 | ADORA3 (0.41) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL12944924 | 0.75 | HRH3 (0.40) | KDM4EALDH1A1SMN1; SMN2CHRM2CHRM1 | |
| SCHEMBL8142324 | 0.67 | KDM4E (0.42) | KDM4EPOLBSIGMAR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7386585 | 0.66 | KDM4E (0.40) | KDM4EPOLBALDH1A1KCNH2MEN1 | |
| Hydrochloric Acid SCHEMBL8133640 | 0.66 | KDM4E (0.41) | KDM4EPOLBSIGMAR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4498957 | 0.64 | FABP4 (0.46) | KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL7364843 | 0.62 | SIGMAR1 (0.42) | KDM4EPOLBSIGMAR1KCNH2HTR2C | |
| SCHEMBL7372062 | 0.61 | SIGMAR1 (0.43) | KDM4EPOLBSIGMAR1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994859-A1 | COMPOUNDS | Astra Aktiebolag (publ) (SE) | 2000-04-26 | — | — | EP | claimed |
| WO-1999001437-A1 | COMPOUNDS | ASTRA AKTIEBOLAG (PUBL) (SE) | 1999-01-14 | — | — | WO | claimed |
| EP-0994859-A1 | COMPOUNDS | Astra Aktiebolag (publ) (SE) | 2000-04-26 | — | — | EP | disclosed |
| WO-1999001437-A1 | COMPOUNDS | ASTRA AKTIEBOLAG (PUBL) (SE) | 1999-01-14 | — | — | WO | disclosed |