Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | KMO | O15229 | 2/20 | 0.35 |
| ▸ | ACP1 | P24666 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7386585 | 0.84 | KDM4E (0.40) | KDM4EKCNH2POLBHRH3ALDH1A1 | |
| SCHEMBL7368048 | 0.80 | KDM4E (0.43) | KDM4EKCNH2POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL11931998 | 0.70 | HRH3 (0.39) | KDM4EPOLBHRH3ALDH1A1SMN1; SMN2 | |
| SCHEMBL7916262 | 0.69 | KDM4E (0.39) | KDM4EKCNH2POLBHRH3ALDH1A1 | |
| SCHEMBL7383690 | 0.65 | KDM4E (0.35) | KDM4EKCNH2POLBHRH3ALDH1A1 | |
| SCHEMBL7385477 | 0.64 | SIGMAR1 (0.38) | KDM4EKCNH2POLBHRH3ALDH1A1 | |
| SCHEMBL27994789 | 0.60 | SIGMAR1 (0.55) | KDM4EKCNH2ALDH1A1SMN1; SMN2SIGMAR1 | |
| SCHEMBL21741655 | 0.59 | KDM4E (0.48) | KDM4EHRH3ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9476734 | 0.59 | ALDH1A1 (0.52) | KDM4EPOLBALDH1A1SMN1; SMN2SIGMAR1 | |
| SCHEMBL28153444 | 0.57 | AHR (0.52) | KDM4EALDH1A1SMN1; SMN2CYP1A2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993450-A1 | NEW COMPOUNDS | Astra Aktiebolag (publ) (SE) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001438-A1 | NEW COMPOUNDS | ASTRA AKTIEBOLAG (PUBL) (SE) | 1999-01-14 | — | — | WO | disclosed |