Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 5/20 | 0.49 |
| ▸ | HTR3A | P46098 | 2/20 | 0.49 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2089327 | 0.84 | CHRNA7 (0.64) | SMN1; SMN2KDM4ECHRNA7HTR3AYTHDC1 | |
| SCHEMBL14390875 | 0.79 | CHRNA7 (0.52) | SMN1; SMN2KDM4ECHRNA7HTR3AYTHDC1 | |
| SCHEMBL4748095 | 0.78 | RAB9A (0.48) | SMN1; SMN2KDM4ECHRNA7HTR3AYTHDC1 | |
| SCHEMBL2086156 | 0.77 | CHRNA7 (0.64) | SMN1; SMN2KDM4ECHRNA7HTR3AYTHDC1 | |
| SCHEMBL12441910 | 0.77 | CHRNA7 (0.64) | SMN1; SMN2KDM4ECHRNA7HTR3AYTHDC1 | |
| SCHEMBL6957369 | 0.76 | GSK3B (0.70) | SMN1; SMN2KDM4E | |
| SCHEMBL5433264 | 0.75 | RAB9A (0.61) | SMN1; SMN2KDM4ECHRNA7HTR3AYTHDC1 | |
| SCHEMBL30068530 | 0.75 | RAB9A (0.61) | SMN1; SMN2KDM4ECHRNA7HTR3AYTHDC1 | |
| SCHEMBL7368122 | 0.75 | CHRNA7 (0.45) | KDM4ECHRNA7HTR3AYTHDC1NPC1 | |
| SCHEMBL2217879 | 0.73 | CHRNA7 (0.58) | SMN1; SMN2KDM4ECHRNA7HTR3AYTHDC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0200444-A2 | Azabicyclononyl-indazole-carboxamide having 5-HT antagonist activity | BEECHAM GROUP PLC (GB) | 1986-11-05 | — | — | EP | claimed |