SCHEMBL7368182

SCHEMBL7368182

Nc1cc(-c2ccccc2S(N)(=O)=O)ccn1

nearest known ligand 0.56

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALOX5AP P20292 7/20 0.56
FEN1 P39748 7/20 0.56
PIK3C3 Q8NEB9 1/20 0.46
S1PR1 P21453 1/20 0.44
CA12 O43570 1/20 0.43
CA1 P00915 1/20 0.43
CA2 P00918 1/20 0.43
CYP2C9 P11712 1/20 0.43
CA4 P22748 1/20 0.43
CA6 P23280 1/20 0.43
CA5A P35218 1/20 0.43
CA7 P43166 1/20 0.43
CA9 Q16790 1/20 0.43
CA14 Q9ULX7 1/20 0.43
CA5B Q9Y2D0 1/20 0.43
TRPV1 Q8NER1 2/20 0.41
PTGES2 Q9H7Z7 1/20 0.41
MKNK1 Q9BUB5 1/20 0.41
MKNK2 Q9HBH9 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1990221 0.78 LRRK2 (0.49) ALOX5APFEN1CA12CA1CA2
SCHEMBL29442129 0.78 LRRK2 (0.49) ALOX5APFEN1CA12CA1CA2
SCHEMBL6237306 0.75 ALOX5AP (0.77) ALOX5APFEN1
SCHEMBL6613230 0.75 CA1 (0.54) ALOX5APFEN1CA12CA1CA2
SCHEMBL8350056 0.74 CA1 (0.54) ALOX5APFEN1CA12CA1CA2
SCHEMBL16177854 0.73 ALOX5AP (0.48) ALOX5APFEN1CA12CA1CA2
SCHEMBL48885 0.73 CA2 (0.52) ALOX5APFEN1CA12CA1CA2
SCHEMBL3362961 0.73 PIK3C3 (0.61) ALOX5APFEN1PIK3C3MKNK1MKNK2
SCHEMBL3363667 0.73 CTSD (0.53) ALOX5APFEN1PIK3C3CYP2C9
SCHEMBL6185772 0.72 ALOX5AP (0.51) ALOX5APFEN1CA12CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6043257-A ANTICOAGULANT; PYRIDINE SUBSTITUTED INDAZOLE COMPOUND E. I. DU PONT DE NEMOURS AND COMPANY (US) 2000-03-28 US disclosed
EP-0960102-A1 AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN Du Pont Pharmaceuticals Company (US) 1999-12-01 EP disclosed
US-5886191-A ANTICOAGULANTS DUPONT PHARMACEUTICALS COMPANY (US) 1999-03-23 US disclosed
WO-1998001428-A1 AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN DU PONT PHARMACEUTICALS COMPANY (US) 1998-01-15 WO disclosed