Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LNPEP | Q9UIQ6 | 5/20 | 0.41 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.40 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.40 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.40 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.40 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.39 |
| ▸ | LTA4H | P09960 | 2/20 | 0.38 |
| ▸ | MMP3 | P08254 | 4/20 | 0.38 |
| ▸ | HRAS | P01112 | 2/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7358533 | 0.92 | MMP3 (0.39) | LNPEPERAP2MMP3MMP1MMP2 | |
| SCHEMBL7355861 | 0.90 | PSMB1 (0.41) | LNPEPPSMB1PSMB9PSMB5PSMB10 | |
| SCHEMBL7356789 | 0.90 | MMP3 (0.43) | MMP3MMP1MMP2 | |
| SCHEMBL7361335 | 0.86 | MMP3 (0.42) | LNPEPERAP2MMP3MMP1MMP2 | |
| SCHEMBL7394273 | 0.84 | ITGB3 (0.44) | LNPEPERAP2HRAS | |
| SCHEMBL7423322 | 0.81 | ERAP2 (0.40) | LNPEPERAP2MMP3MMP1MMP2 | |
| SCHEMBL7396119 | 0.81 | MMP3 (0.44) | MMP3MMP1MMP2 | |
| SCHEMBL7360307 | 0.80 | LIMK2 (0.40) | MMP1MMP2 | |
| SCHEMBL7358575 | 0.80 | PTPN1 (0.46) | LNPEPPSMB1PSMB9PSMB5PSMB10 | |
| SCHEMBL7364939 | 0.80 | ERAP2 (0.40) | LNPEPERAP2MMP3MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998025949-A1 | SUBSTITUTED 5-AMINO-1,3,4-THIADIAZOLE-2-THIONES | PROSCRIPT, INC. (US) | 1998-06-18 | — | — | WO | disclosed |
| EP-0845002-A2 | AMINO ACID AMIDES OF 5-AMINO-1,3,4-THIADIAZONES AND THEIR USE AS INHIBITORS FOR MATRIX METALLOPROTEINASES | PROSCRIPT, INC. (US) | 1998-06-03 | — | — | EP | disclosed |
| US-5677282-A | ENZYME INHIBITOR; OSTEOARTHRITIS AND RHEUMATIC DISORDERS | PROSCRIPT, INC. (US) | 1997-10-14 | — | — | US | disclosed |
| WO-1996040745-A2 | AMINO ACID AMIDES OF 5-AMINO-1,3,4-THIADIAZONES AND THEIR USE AS INHIBITORS FOR MATRIX METALLOPROTEINASES | PROSCRIPT, INC. (US) | 1996-12-19 | — | — | WO | disclosed |