Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 8/20 | 0.59 |
| ▸ | PDE4A | P27815 | 7/20 | 0.59 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.59 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7368236 | 0.82 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DGAA | |
| SCHEMBL7369053 | 0.80 | ALDH1A1 (0.65) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL7358558 | 0.74 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DPDGFRB | |
| SCHEMBL14570529 | 0.72 | PDE4B (0.77) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7355649 | 0.72 | PDE4B (0.82) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7366624 | 0.71 | PDE4B (0.62) | PDE4BPDE4APDE4CPDE4DHPGD | |
| SCHEMBL7360400 | 0.71 | PDE4B (0.67) | PDE4BPDE4APDE4CPDE4DPDGFRB | |
| SCHEMBL7359192 | 0.71 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4DPDGFRB | |
| Hydrochloric Acid SCHEMBL7363927 | 0.70 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4DPDGFRB | |
| SCHEMBL7333823 | 0.70 | PDE4B (0.71) | PDE4BPDE4APDE4CPDE4DPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0672031-A1 | CATECHOL DIETHERS AS SELECTIVE PDE IV? INHIBITORS | PFIZER INC. (US) | 1995-09-20 | — | — | EP | disclosed |
| WO-1994012461-A1 | CATECHOL DIETHERS AS SELECTIVE PDEIV INHIBITORS | PFIZER INC. (US) | 1994-06-09 | — | — | WO | disclosed |