Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 5/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MMP2 | P08253 | 4/20 | 0.54 |
| ▸ | MMP9 | P14780 | 4/20 | 0.54 |
| ▸ | MMP8 | P22894 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.51 |
| ▸ | MMP7 | P09237 | 1/20 | 0.51 |
| ▸ | MMP12 | P39900 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MMP1 | P03956 | 1/20 | 0.50 |
| ▸ | MMP3 | P08254 | 1/20 | 0.50 |
| ▸ | RRM1 | P23921 | 1/20 | 0.46 |
| ▸ | RRM2 | P31350 | 1/20 | 0.46 |
| ▸ | RRM2B | Q7LG56 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7763152 | 0.85 | MMP2 (0.75) | MMEMMP2MMP9MMP8MMP7 | |
| SCHEMBL11412632 | 0.84 | MME (0.58) | MMEALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL21994104 | 0.83 | MME (0.67) | MMEALDH1A1MMP2MMP9MMP8 | |
| SCHEMBL9067110 | 0.82 | MME (0.67) | MMEALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL8897160 | 0.81 | ALDH1A1 (0.60) | MMEALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL11122736 | 0.81 | MME (0.76) | MMEMMP2MMP9MMP7MMP12 | |
| SCHEMBL11119164 | 0.81 | MME (0.76) | MMEMMP2MMP9MMP7MMP12 | |
| SCHEMBL11122734 | 0.81 | MME (0.76) | MMEMMP2MMP9MMP7MMP12 | |
| SCHEMBL11122302 | 0.81 | MME (0.76) | MMEMMP2MMP9MMP7MMP12 | |
| SCHEMBL11119167 | 0.81 | MME (0.76) | MMEMMP2MMP9MMP7MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028716-A1 | METHOD FOR TREATING AND PREVENTING HEART FAILURE AND VENTRICULAR DILATATION | WARNER-LAMBERT COMPANY (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1998025597-A2 | METHOD FOR TREATING AND PREVENTING HEART FAILURE AND VENTRICULAR DILATATION | WARNER-LAMBERT COMPANY (US) | 1998-06-18 | — | — | WO | disclosed |
| EP-0793643-A1 | MATRIX METALLOPROTEASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1997-09-10 | — | — | EP | disclosed |
| EP-0726903-A1 | MATRIX METALLOPROTEASE INHIBITORS | SYNTEX INC (US) | 1996-08-21 | — | — | EP | disclosed |
| WO-1996016027-A1 | MATRIX METALLOPROTEASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1996-05-30 | — | — | WO | disclosed |
| WO-1995012603-A1 | MATRIX METALLOPROTEASE INHIBITORS________________________________ | SYNTEX (U.S.A.) INC. (US) | 1995-05-11 | — | — | WO | disclosed |