Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 10/20 | 0.75 |
| ▸ | MMP9 | P14780 | 9/20 | 0.75 |
| ▸ | MMP8 | P22894 | 6/20 | 0.75 |
| ▸ | MMP7 | P09237 | 4/20 | 0.69 |
| ▸ | MMP13 | P45452 | 3/20 | 0.69 |
| ▸ | MMP12 | P39900 | 2/20 | 0.69 |
| ▸ | BIRC2 | Q13490 | 4/20 | 0.61 |
| ▸ | MME | P08473 | 2/20 | 0.60 |
| ▸ | MMP1 | P03956 | 9/20 | 0.59 |
| ▸ | MMP3 | P08254 | 6/20 | 0.59 |
| ▸ | FCER2 | P06734 | 3/20 | 0.59 |
| ▸ | MMP14 | P50281 | 2/20 | 0.57 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4288816 | 0.85 | MMP2 (0.63) | MMP2MMP9MMP8MMP7MMP13 | |
| SCHEMBL11412351 | 0.85 | MMP2 (0.55) | MMP2MMP9MMP8MMP7MMP13 | |
| SCHEMBL7368385 | 0.85 | MME (0.81) | MMP2MMP9MMP8MMP7MMP13 | |
| SCHEMBL9284706 | 0.84 | MMP9 (0.70) | MMP2MMP9MMP8MMP7MMP13 | |
| SCHEMBL29843442 | 0.83 | MMP9 (0.74) | MMP2MMP9MMP8MMP7MMP13 | |
| SCHEMBL10424911 | 0.83 | MMP2 (0.60) | MMP2MMP9MMP8MMP7MMP13 | |
| SCHEMBL8269110 | 0.81 | MME (0.61) | MMP2MMP9MMP8MMP7MMP13 | |
| SCHEMBL8601655 | 0.81 | MMP2 (0.65) | MMP2MMP9MMP8MMP7MMP13 | |
| SCHEMBL7374287 | 0.80 | MMP1 (0.58) | MMP2MMP9MMP8MMP7MMP13 | |
| SCHEMBL9067110 | 0.78 | MME (0.67) | MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098662-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2001-05-16 | — | — | EP | disclosed |
| WO-2000004892-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2000-02-03 | — | — | WO | disclosed |