Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 5/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | ECE1 | P42892 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ACE | P12821 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2871612 | 0.95 | MME (0.68) | MMEALDH1A1ECE1MEN1LMNA | |
| SCHEMBL11433538 | 0.90 | MME (0.63) | MMEALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL7407245 | 0.88 | MME (0.58) | MMEALDH1A1ECE1MEN1LMNA | |
| SCHEMBL7407242 | 0.88 | MME (0.58) | MMEALDH1A1ECE1MEN1LMNA | |
| SCHEMBL7407238 | 0.88 | MME (0.58) | MMEALDH1A1ECE1MEN1LMNA | |
| SCHEMBL7415847 | 0.88 | MME (0.58) | MMEALDH1A1ECE1MEN1LMNA | |
| SCHEMBL9068565 | 0.84 | ALDH1A1 (0.58) | MMEALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL9068566 | 0.84 | ALDH1A1 (0.58) | MMEALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL9068638 | 0.84 | MME (0.58) | MMEECE1ACE | |
| SCHEMBL11325012 | 0.83 | MME (0.56) | MMEALDH1A1MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726903-A1 | MATRIX METALLOPROTEASE INHIBITORS | SYNTEX INC (US) | 1996-08-21 | — | — | EP | disclosed |
| US-5496805-A | DIURETIC, HYPOTENSIVE | E. R. SQUIBB & SONS, INC. (US) | 1996-03-05 | — | — | US | disclosed |
| WO-1995012603-A1 | MATRIX METALLOPROTEASE INHIBITORS________________________________ | SYNTEX (U.S.A.) INC. (US) | 1995-05-11 | — | — | WO | disclosed |