Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.45 |
| ▸ | CCR2 | P41597 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | ACLY | P53396 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7320114 | 0.87 | RAB9A (0.55) | RAB9ATDP1MAPK8CCR2LMNA | |
| SCHEMBL7365849 | 0.84 | CYP1A2 (0.51) | RAB9ATDP1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL2336921 | 0.81 | RAB9A (0.54) | RAB9ATDP1MAPK8LMNASMN1; SMN2 | |
| SCHEMBL10967902 | 0.80 | SCN9A (0.48) | RAB9ATDP1MAPK8PDE10APPARG | |
| SCHEMBL11814538 | 0.80 | TDP1 (0.57) | RAB9ATDP1MAPK8PDE10AALDH1A1 | |
| SCHEMBL2779334 | 0.79 | RAB9A (0.76) | RAB9ATDP1MAPK8LMNASMN1; SMN2 | |
| SCHEMBL7374880 | 0.79 | MEN1 (0.63) | TDP1MAPK8PDE10AALDH1A1 | |
| SCHEMBL2332693 | 0.79 | ALDH1A1 (0.61) | RAB9ATDP1MAPK8LMNASMN1; SMN2 | |
| SCHEMBL2781858 | 0.79 | TDP1 (0.52) | RAB9ATDP1MAPK8LMNAPDE10A | |
| SCHEMBL2335696 | 0.79 | GPBAR1 (0.60) | RAB9ATDP1CCR2LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |