Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KMO | O15229 | 2/20 | 0.51 |
| ▸ | CCR2 | P41597 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | CCR3 | P51677 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2336921 | 0.88 | RAB9A (0.54) | RAB9ATDP1LMNASMN1; SMN2MAPK8 | |
| SCHEMBL7368546 | 0.87 | RAB9A (0.50) | RAB9ACCR2TDP1LMNASMN1; SMN2 | |
| SCHEMBL10976046 | 0.85 | TDP1 (0.67) | RAB9ACCR2TDP1MAPK8ALDH1A1 | |
| SCHEMBL10967902 | 0.84 | SCN9A (0.48) | RAB9ATDP1MAPK8PDE10A | |
| SCHEMBL2779334 | 0.84 | RAB9A (0.76) | RAB9ATDP1LMNASMN1; SMN2MAPK8 | |
| SCHEMBL2332693 | 0.83 | ALDH1A1 (0.61) | RAB9ATDP1LMNASMN1; SMN2MAPK8 | |
| SCHEMBL2782132 | 0.81 | MAPK8 (0.53) | RAB9ATDP1LMNAMAPK8ALDH1A1 | |
| SCHEMBL6460814 | 0.80 | CARM1 (0.52) | RAB9ATDP1MAPK8ALDH1A1PDE10A | |
| SCHEMBL7431657 | 0.80 | CCR2 (0.50) | RAB9ACCR2TDP1LMNASMN1; SMN2 | |
| SCHEMBL2781858 | 0.80 | TDP1 (0.52) | RAB9ATDP1LMNAMAPK8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0357316-B1 | ANTIDEPRESSANT N-SUBSTITUTED NICOTINAMIDE COMPOUNDS | PFIZER INC. (US) | 1993-04-14 | — | — | EP | disclosed |
| EP-0357316-A1 | Antidepressant N-substituted nicotinamide compounds | PFIZER INC. (US) | 1990-03-07 | — | — | EP | disclosed |
| US-4861891-A | Antidepressant N-substituted nicotinamide compounds | PFIZER INC. (US) | 1989-08-29 | — | — | US | disclosed |
| EP-0053011-B1 | NEW HERBICIDAL NICOTINAMIDE DERIVATIVES | MAY & BAKER LIMITED (GB) | 1985-04-03 | — | — | EP | disclosed |
| EP-0053011-A1 | New herbicidal nicotinamide derivatives | MAY & BAKER LIMITED (GB) | 1982-06-02 | — | — | EP | disclosed |