SCHEMBL7368565

SCHEMBL7368565

COc1cccc(-c2oc(=O)c3ccc[nH]c2-3)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.50
HPGD P15428 4/20 0.50
KMT2A Q03164 2/20 0.50
F2 P00734 1/20 0.50
MAOB P27338 4/20 0.46
MIF P14174 1/20 0.45
NOTUM Q6P988 1/20 0.45
LMNA P02545 1/20 0.45
MAPT P10636 3/20 0.44
HSD17B10 Q99714 2/20 0.44
KDM4E B2RXH2 3/20 0.43
CYP3A4 P08684 2/20 0.43
MAPK1 P28482 2/20 0.43
TP53 P04637 2/20 0.43
MEN1 O00255 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C9 P11712 1/20 0.43
TSHR P16473 1/20 0.43
ALOX12 P18054 1/20 0.43
CYP2C19 P33261 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7367312 0.85 ALDH1A1 (0.47) ALDH1A1HPGDKMT2AMAOBMIF
SCHEMBL7365563 0.81 CDK8 (0.46) ALDH1A1KMT2AMAPTNPC1RAB9A
SCHEMBL7361674 0.80 MAOB (0.42) ALDH1A1KMT2AMAOBMAPTHSD17B10
SCHEMBL7359478 0.80 MIF (0.42) ALDH1A1HPGDKMT2AMAOBMIF
SCHEMBL7363661 0.75 MEN1 (0.51) ALDH1A1KMT2AMAOBLMNAMAPT
SCHEMBL7370353 0.73 MAOB (0.53) ALDH1A1HPGDKMT2AF2MAOB
SCHEMBL7366172 0.71 GAPDH (0.47) ALDH1A1HPGDKMT2AMIFLMNA
SCHEMBL7368721 0.70 KMT2A (0.43) ALDH1A1KMT2AF2MAOBLMNA
SCHEMBL31237068 0.69 GAA (0.56) ALDH1A1NOTUMLMNAMAPTKDM4E
SCHEMBL7443518 0.69 GAA (0.56) ALDH1A1NOTUMLMNAMAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5716954-A ANTIINFLAMMATORY AGENT, ANTIHISTAMINES, IMMUNOSUPPRESSION,AUTOIMMUNE DISEASES SYNTEX U.S.A. INC. (US) 1998-02-10 US disclosed
EP-0612321-A1 PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY SYNTEX (U.S.A.) INC. (US) 1994-08-31 EP disclosed
WO-1993007146-A1 BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY SYNTEX (U.S.A.) INC. (US) 1993-04-15 WO disclosed