Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7368926 | 0.85 | CDK4 (0.47) | MAOBADORA1ALDH1A1LMNAPDGFRB | |
| SCHEMBL7365581 | 0.81 | CDK8 (0.48) | ALDH1A1HPGDDHODHKDM5B | |
| SCHEMBL7370627 | 0.81 | MAOB (0.51) | MAOBADORA2AADORA1ALDH1A1HPGD | |
| SCHEMBL7366344 | 0.80 | MAOB (0.50) | MAOBALDH1A1LMNAHPGDKMT2A | |
| SCHEMBL7362866 | 0.76 | MEN1 (0.44) | ALDH1A1KMT2AGAAPKMMEN1 | |
| SCHEMBL7369411 | 0.75 | RAB9A (0.42) | ALDH1A1HPGDKMT2APKMMEN1 | |
| SCHEMBL7364007 | 0.73 | IDO1 (0.48) | ALDH1A1LMNAHPGDDHODHKDR | |
| SCHEMBL7368565 | 0.73 | ALDH1A1 (0.50) | MAOBALDH1A1LMNAHPGDKMT2A | |
| SCHEMBL7364174 | 0.71 | KDR (0.46) | ADORA2AADORA1ALDH1A1LMNAKMT2A | |
| SCHEMBL7443518 | 0.71 | GAA (0.56) | ALDH1A1LMNAGAANOTUMHDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |