Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 4/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7363061 | 0.80 | USP2 (0.50) | USP2CYP2D6CYP2C9CYP1A2CYP3A4 | |
| SCHEMBL4749593 | 0.70 | USP2 (0.47) | USP2CYP2D6CYP2C9CYP1A2CYP3A4 | |
| SCHEMBL4746204 | 0.66 | USP2 (0.44) | USP2CYP2D6CYP2C9CYP1A2CYP3A4 | |
| SCHEMBL8118275 | 0.66 | USP2 (0.41) | USP2CYP2D6CYP2C9CYP1A2CYP3A4 | |
| SCHEMBL15463712 | 0.65 | HTR2A (0.39) | USP2CYP2D6CYP2C9CYP1A2CYP3A4 | |
| SCHEMBL10639868 | 0.65 | HRH1 (0.43) | USP2CYP2D6CYP2C9CYP1A2CYP3A4 | |
| SCHEMBL16593917 | 0.64 | OPRM1 (0.43) | OPRM1OPRD1OPRK1OPRL1SIGMAR1 | |
| SCHEMBL10413788 | 0.64 | SLC6A4 (0.69) | CYP2D6CYP2C9CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL7522574 | 0.63 | SLC6A2 (0.38) | CYP2D6CYP2C9CYP2C19OPRM1OPRD1 | |
| SCHEMBL4749321 | 0.62 | USP2 (0.44) | USP2CYP2D6CYP2C9CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714292-A4 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | CAMBRIDGE NEUROSCIENCE INC (US) | 1996-10-09 | — | — | EP | claimed |
| EP-0714292-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1996-06-05 | — | — | EP | claimed |
| WO-1995000131-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | CAMBRIDGE NEUROSCIENCE, INCORPORATED (US) | 1995-01-05 | — | — | WO | claimed |