Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.57 |
| ▸ | KDM4A | O75164 | 2/20 | 0.57 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.57 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.55 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.47 |
| ▸ | KDM6B | O15054 | 1/20 | 0.47 |
| ▸ | KDM6A | O15550 | 1/20 | 0.47 |
| ▸ | TET3 | O43151 | 1/20 | 0.47 |
| ▸ | KDM4B | O94953 | 1/20 | 0.47 |
| ▸ | KDM5C | P41229 | 1/20 | 0.47 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.47 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.47 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.47 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.47 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.47 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.47 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4519716 | 0.91 | KDM4E (0.68) | KDM4EL3MBTL1KDM4AEGLN1RAB9A | |
| Hydrochloric Acid SCHEMBL15328531 | 0.90 | KDM4E (0.66) | KDM4EL3MBTL1KDM4AEGLN1RAB9A | |
| SCHEMBL6962756 | 0.79 | KDM4E (0.68) | KDM4EL3MBTL1KDM4AEGLN1RAB9A | |
| SCHEMBL15328529 | 0.77 | KDM4E (0.49) | KDM4EL3MBTL1KDM4AEGLN1RAB9A | |
| SCHEMBL69905 | 0.76 | KDM4E (0.74) | KDM4EL3MBTL1KDM4AEGLN1RAB9A | |
| SCHEMBL7370804 | 0.74 | PREP (0.50) | KDM4EL3MBTL1KDM4AEGLN1RAB9A | |
| SCHEMBL7377364 | 0.74 | PSMD14 (0.68) | KDM4EL3MBTL1KDM4AEGLN1RAB9A | |
| SCHEMBL15328824 | 0.74 | SLC40A1 (0.56) | KDM4EL3MBTL1KDM4AEGLN1RAB9A | |
| SCHEMBL298623 | 0.73 | KDM4E (1.00) | KDM4EL3MBTL1KDM4AEGLN1RAB9A | |
| SCHEMBL23754362 | 0.72 | KDM4E (0.68) | KDM4EL3MBTL1KDM4AEGLN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6410529-B1 | DIETETICS; NON-INSULIN DEPENDENT DIABETES; SLEEP DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-06-25 | — | — | US | disclosed |
| EP-1003737-A1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS HFGAN72 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999009024-A1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS HFGAN72 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-02-25 | — | — | WO | disclosed |