Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | LTA4H | P09960 | 2/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | NPY1R | P25929 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7373567 | 0.93 | SMN1; SMN2 (0.62) | HRH3ALDH1A1SMN1; SMN2LTA4HABCB1 | |
| SCHEMBL7906481 | 0.93 | SMN1; SMN2 (0.62) | HRH3ALDH1A1SMN1; SMN2LTA4HABCB1 | |
| SCHEMBL7383210 | 0.92 | ALDH1A1 (0.64) | HRH3ALDH1A1SMN1; SMN2LTA4HABCB1 | |
| SCHEMBL5396713 | 0.89 | LTA4H (0.53) | HRH3ALDH1A1SMN1; SMN2LTA4HABCB1 | |
| SCHEMBL7368346 | 0.89 | HRH3 (0.60) | HRH3ALDH1A1SMN1; SMN2ABCB1NPC1 | |
| SCHEMBL7364513 | 0.88 | KDM4E (0.59) | HRH3ALDH1A1SMN1; SMN2LTA4HNPC1 | |
| SCHEMBL5410167 | 0.88 | LTA4H (0.54) | HRH3ALDH1A1SMN1; SMN2LTA4HNPC1 | |
| SCHEMBL7535886 | 0.84 | HRH3 (0.47) | HRH3ALDH1A1SMN1; SMN2LTA4HKDM4E | |
| SCHEMBL7531660 | 0.84 | HRH3 (0.47) | HRH3ALDH1A1SMN1; SMN2LTA4HKDM4E | |
| SCHEMBL7537859 | 0.83 | SIGMAR1 (0.53) | HRH3ALDH1A1SMN1; SMN2LTA4HNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057332-A | Substituted 1,4-dihydropyrimidine-5-carboxylate compounds, their preparation and uses | ASTRA AKTIEBOLAG (SE) | 2000-05-02 | — | — | US | disclosed |
| EP-0994859-A1 | COMPOUNDS | Astra Aktiebolag (publ) (SE) | 2000-04-26 | — | — | EP | disclosed |
| WO-1999001437-A1 | COMPOUNDS | ASTRA AKTIEBOLAG (PUBL) (SE) | 1999-01-14 | — | — | WO | disclosed |