SCHEMBL7537859

SCHEMBL7537859

CN1CCN(CCOCC(=O)CC(=O)OCCCc2ccccc2)CC1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 4/20 0.53
ALDH1A1 P00352 3/20 0.52
SMN1; SMN2 Q16637 3/20 0.52
MEN1 O00255 1/20 0.49
POLB P06746 1/20 0.49
KMT2A Q03164 1/20 0.49
HRH3 Q9Y5N1 4/20 0.46
ITGB3 P05106 1/20 0.45
ITGA2B P08514 1/20 0.45
FAAH O00519 1/20 0.45
RAB9A P51151 2/20 0.44
TP53 P04637 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP2D6 P10635 1/20 0.44
MAPT P10636 1/20 0.44
CYP2C9 P11712 1/20 0.44
ALOX15 P16050 1/20 0.44
TSHR P16473 1/20 0.44
NFKB1 P19838 1/20 0.44
SLC6A2 P23975 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7383210 0.91 ALDH1A1 (0.64) SIGMAR1ALDH1A1SMN1; SMN2MEN1POLB
SCHEMBL7906481 0.90 SMN1; SMN2 (0.62) SIGMAR1ALDH1A1SMN1; SMN2MEN1POLB
SCHEMBL7373567 0.90 SMN1; SMN2 (0.62) SIGMAR1ALDH1A1SMN1; SMN2MEN1POLB
SCHEMBL7368346 0.86 HRH3 (0.60) SIGMAR1ALDH1A1SMN1; SMN2MEN1POLB
SCHEMBL7368858 0.83 HRH3 (0.52) SIGMAR1ALDH1A1SMN1; SMN2HRH3RAB9A
SCHEMBL7370485 0.80 MAPT (0.54) SIGMAR1ALDH1A1SMN1; SMN2POLBKMT2A
SCHEMBL10966316 0.80 ALDH1A1 (0.59) SIGMAR1ALDH1A1SMN1; SMN2MEN1POLB
SCHEMBL7385644 0.79 ALDH1A1 (0.48) SIGMAR1ALDH1A1SMN1; SMN2HRH3RAB9A
SCHEMBL8143235 0.79 TDP1 (0.50) ALDH1A1SMN1; SMN2MEN1POLBKMT2A
SCHEMBL7383838 0.78 CHRNA7 (0.49) SIGMAR1ALDH1A1SMN1; SMN2HRH3LTA4H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6218538-B1 ANTAGONISTS OF N-TYPE NEURONAL CALCIUM CHANNELS USEFUL IN THE TREATMENT OF CEREBROVASCULAR ISCHAEMIA AND PAIN. ASTRA AKTIEBOLAG (SE) 2001-04-17 US disclosed
EP-0993450-A1 NEW COMPOUNDS Astra Aktiebolag (publ) (SE) 2000-04-19 EP disclosed
WO-1999001438-A1 NEW COMPOUNDS ASTRA AKTIEBOLAG (PUBL) (SE) 1999-01-14 WO disclosed