SCHEMBL7368874

SCHEMBL7368874

O=C(O)c1ccc(NC(=O)C(Cc2ccccc2)CP(=O)(O)O)cc1

nearest known ligand 0.70

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FOLH1 Q04609 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7363583 0.85 RAB9A (0.60) SMN1; SMN2
SCHEMBL8861680 0.83 MME (0.56)
SCHEMBL10395960 0.82 CYP1A2 (0.53) FOLH1SMN1; SMN2
SCHEMBL10395962 0.82 CYP1A2 (0.53) FOLH1SMN1; SMN2
SCHEMBL390864 0.82 MME (0.57) FOLH1
SCHEMBL7364836 0.80 ROCK2 (0.51) FOLH1
SCHEMBL7381948 0.78 CYP1A2 (0.46)
SCHEMBL7300551 0.77 MEN1 (0.51) SMN1; SMN2
SCHEMBL28703199 0.77 MEN1 (0.51) SMN1; SMN2
SCHEMBL7299745 0.77 MEN1 (0.51) SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0117429-B1 PHOSPHOROUS CONTAINING COMPOUNDS AS INHIBITORS OF ENKEPHALINASES SCHERING CORPORATION (US) 1987-09-02 EP claimed
EP-0117429-A1 Phosphorous containing compounds as inhibitors of enkephalinases SCHERING CORPORATION (US) 1984-09-05 EP claimed
EP-0117429-B1 PHOSPHOROUS CONTAINING COMPOUNDS AS INHIBITORS OF ENKEPHALINASES SCHERING CORPORATION (US) 1987-09-02 EP disclosed