Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.41 |
| ▸ | LTA4H | P09960 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL243134 | 0.83 | ALDH1A1 (0.53) | TDP1FEN1ALDH1A1LTA4H | |
| SCHEMBL14354842 | 0.80 | ALDH1A1 (0.41) | LMNAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL4907190 | 0.80 | LMNA (0.50) | LMNATDP1FEN1MAP4K4CYP11B1 | |
| SCHEMBL15923259 | 0.79 | LMNA (0.52) | LMNATDP1FEN1MAP4K4CYP11B1 | |
| SCHEMBL993054 | 0.78 | LMNA (0.47) | LMNATDP1FEN1MAP4K4CYP11B1 | |
| SCHEMBL11478665 | 0.76 | LMNA (0.53) | LMNATDP1MAP4K4CYP11B1CYP11B2 | |
| SCHEMBL676142 | 0.76 | LMNA (0.82) | LMNATDP1MAP4K4CYP11B1CYP11B2 | |
| SCHEMBL30535283 | 0.76 | LMNA (0.82) | LMNATDP1MAP4K4CYP11B1CYP11B2 | |
| SCHEMBL14030952 | 0.76 | DGAT2 (0.39) | FEN1CHRNB2CHRNA4 | |
| SCHEMBL14005471 | 0.76 | P2RY1 (0.36) | LMNAFEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |