SCHEMBL7368928

SCHEMBL7368928

O=S(=O)(c1ccccc1)c1ccc(-c2ccnn2-c2ccc(F)cc2F)nn1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.37
RAB9A P51151 1/20 0.37
HTR2A P28223 3/20 0.36
HTR2C P28335 2/20 0.36
KCNH2 Q12809 2/20 0.36
NR3C2 P08235 3/20 0.35
KDM4A O75164 1/20 0.34
KDM5A P29375 1/20 0.34
KDM4C Q9H3R0 1/20 0.34
KDM5B Q9UGL1 1/20 0.34
LMNA P02545 3/20 0.34
NPSR1 Q6W5P4 2/20 0.34
HSP90AA1 P07900 1/20 0.34
KDM4E B2RXH2 1/20 0.34
ALDH1A1 P00352 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
GAA P10253 1/20 0.34
HPGD P15428 1/20 0.34
RXFP1 Q9HBX9 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7366842 0.83 NR3C2 (0.43) NPC1RAB9ANR3C2KDM5AKDM4C
SCHEMBL27343295 0.80 CYP2C9 (0.45) NR3C2LMNANPSR1CYP3A4TP53
SCHEMBL7370829 0.79 NR3C2 (0.44) NPC1RAB9ANR3C2NPSR1KDM4E
SCHEMBL7370147 0.77 PTGS1 (0.38) LMNANPSR1KDM4EALDH1A1CYP3A4
SCHEMBL7369553 0.72 HTT (0.47) NR3C2LMNANPSR1HSP90AA1KDM4E
SCHEMBL7364220 0.68 HTR2A (0.40) HTR2AHTR2CKCNH2LMNAALDH1A1
SCHEMBL10354233 0.66 HTR6 (0.62) KDM4EALDH1A1TP53SMN1; SMN2HTR6
SCHEMBL15560513 0.65 KDM5A (0.50) NPC1RAB9ANR3C2KDM4AKDM5A
SCHEMBL15559871 0.64 MAPK14 (0.44) NPC1RAB9ANR3C2KDM5AKDM4C
SCHEMBL776300 0.64 HTR2A (0.54) HTR2AHTR2CKCNH2LMNANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1244669-A1 PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-10-02 EP disclosed
WO-2001040230-A1 PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-06-07 WO disclosed