Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7369553 | 0.86 | HTT (0.47) | ALDH1A1HTTLMNANPSR1KDM4E | |
| SCHEMBL7366842 | 0.84 | NR3C2 (0.43) | LMNANPSR1THRB | |
| SCHEMBL27343295 | 0.81 | CYP2C9 (0.45) | LMNANPSR1CYP3A4PDE10APKM | |
| SCHEMBL7370829 | 0.78 | NR3C2 (0.44) | ALDH1A1NPSR1KDM4EHPGDNR1I2 | |
| SCHEMBL7368928 | 0.77 | NPC1 (0.37) | ALDH1A1LMNANPSR1KDM4EHPGD | |
| SCHEMBL7439517 | 0.72 | HAO1 (0.40) | HTTKDM4ENR1I2GAAF2 | |
| SCHEMBL6983368 | 0.71 | LMNA (0.38) | PTGS1PTGS2ALDH1A1HTTLMNA | |
| SCHEMBL6985834 | 0.67 | ALDH1A1 (0.51) | PTGS2ALDH1A1HTTLMNANPSR1 | |
| SCHEMBL6822095 | 0.67 | MAPK14 (0.39) | PTGS1PTGS2ALDH1A1HTTLMNA | |
| SCHEMBL6981888 | 0.67 | PDE10A (0.46) | ALDH1A1LMNANPSR1GAAPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244669-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001040230-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-06-07 | — | — | WO | disclosed |