Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.38 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7369553 | 0.82 | HTT (0.47) | NR3C2NR1I2GAAALDH1A1KDM4E | |
| SCHEMBL27343295 | 0.81 | CYP2C9 (0.45) | NR3C2TP53TSHRNFKB1POLB | |
| SCHEMBL7368928 | 0.79 | NPC1 (0.37) | NR3C2GAAHTR6ALDH1A1KDM4E | |
| SCHEMBL7370147 | 0.78 | PTGS1 (0.38) | NR1I2GAAALDH1A1KDM4EHPGD | |
| SCHEMBL7366842 | 0.73 | NR3C2 (0.43) | NR3C2KMT2ANPC1TP53MAPT | |
| SCHEMBL6985834 | 0.73 | ALDH1A1 (0.51) | NR1I2GAAHTR6ALDH1A1KDM4E | |
| SCHEMBL6983368 | 0.70 | LMNA (0.38) | NR1I2GFERALDH1A1MEN1KMT2A | |
| SCHEMBL6988697 | 0.68 | NR3C2 (0.43) | NR3C2TP53NPSR1MAPK14 | |
| SCHEMBL6821442 | 0.68 | HTR6 (0.37) | NR1I2GAAHTR6ALDH1A1KDM4E | |
| SCHEMBL6981888 | 0.68 | PDE10A (0.46) | NR3C2GAAALDH1A1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244669-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001040230-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-06-07 | — | — | WO | disclosed |