Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14407776 | 0.87 | MPO (0.57) | MPOSIGMAR1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL1641681 | 0.80 | ALDH1A1 (0.58) | MPOSIGMAR1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL7424735 | 0.79 | ALDH1A1 (0.64) | ALDH1A1KMT2ASMN1; SMN2KDM4EHTT | |
| SCHEMBL2321124 | 0.79 | KMT2A (0.67) | GAAALDH1A1KMT2AMAPTTDP1 | |
| SCHEMBL7418676 | 0.79 | SIGMAR1 (0.67) | SIGMAR1GAAALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL3412153 | 0.79 | MC4R (0.56) | MPOSIGMAR1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL2912056 | 0.78 | ALDH1A1 (0.61) | MPOSIGMAR1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL27535071 | 0.77 | MPO (0.46) | MPOSIGMAR1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL17976019 | 0.76 | MPO (0.50) | MPOSIGMAR1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL7422649 | 0.76 | SIGMAR1 (0.61) | SIGMAR1GAAALDH1A1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929074-A | VSODILATOR, ANTIALLERGIC AND ANTIPLATELET AGENTS | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 1999-07-27 | — | — | US | disclosed |
| EP-0706517-B1 | PYRIDAZINONE DERIVATIVES WITH PHARMACEUTICAL ACTIVITY | NISSAN CHEMICAL IND LTD (JP) | 1998-10-21 | — | — | EP | disclosed |
| US-5728702-A | BRONCHODILATOR AGENTS, ANTIALLERGENS OR ANTIPLATELET DRUGGS | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 1998-03-17 | — | — | US | disclosed |
| WO-1995001343-A1 | PYRIDAZINONE DERIVATIVES WITH PHARMACEUTICAL ACTIVITY | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1995-01-12 | — | — | WO | disclosed |