SCHEMBL7369396

SCHEMBL7369396

CC(C)(Cc1cc(N)ccc1-c1ccccc1)S(N)(=O)=O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.38
ALDH1A1 P00352 2/20 0.38
RAB9A P51151 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
PTGDR2 Q9Y5Y4 1/20 0.38
TP53 P04637 1/20 0.38
CYP3A4 P08684 1/20 0.38
TSHR P16473 1/20 0.38
MAPK1 P28482 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
PTPRC P08575 2/20 0.37
MEN1 O00255 1/20 0.37
APAF1 O14727 1/20 0.37
TDP2 O95551 1/20 0.37
NSD2 O96028 1/20 0.37
LMNA P02545 1/20 0.37
PLA2G1B P04054 1/20 0.37
POLB P06746 1/20 0.37
CTSL P07711 1/20 0.37
HPGD P15428 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9654854 0.83 CA2 (0.34) CA1CA2CA9LOXL2
SCHEMBL8029374 0.82 CA12 (0.38) RAB9ACYP3A4TDP1DPP4CA1
SCHEMBL23057561 0.81 DPP4 (0.41) NPC1ALDH1A1RAB9ASMN1; SMN2PTGDR2
SCHEMBL27656432 0.81 PTGDR2 (0.45) NPC1ALDH1A1RAB9ASMN1; SMN2PTGDR2
SCHEMBL7343883 0.75 CA2 (0.41) TP53MEN1LMNAPOLBKMT2A
SCHEMBL7366245 0.73 ALDH1A1 (0.42) ALDH1A1PTPRCNSD2CA1CA2
SCHEMBL3781497 0.72 DPP4 (0.61) NPC1ALDH1A1RAB9ASMN1; SMN2PTGDR2
SCHEMBL3790106 0.72 PTGDR2 (0.46) NPC1ALDH1A1RAB9ASMN1; SMN2PTGDR2
SCHEMBL7342267 0.71 CA1 (0.35) ALDH1A1TSHRPPARGDPP4CA1
SCHEMBL29795424 0.71 DPP4 (0.41) NPC1ALDH1A1RAB9ASMN1; SMN2PTGDR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0960102-A1 AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN Du Pont Pharmaceuticals Company (US) 1999-12-01 EP disclosed
WO-1998001428-A1 AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN DU PONT PHARMACEUTICALS COMPANY (US) 1998-01-15 WO disclosed