Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364700 | 0.78 | MMP2 (0.48) | KDM4ERAB9ANPC1MAPTCHRM1 | |
| SCHEMBL7364869 | 0.77 | PRKAG1 (0.47) | RAB9ANPC1MAPTFBP1LMNA | |
| SCHEMBL7366603 | 0.73 | NPC1 (0.53) | KDM4ERAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL8726193 | 0.72 | KDM4E (0.42) | KDM4ERAB9ANPC1MAPTDAGLA | |
| SCHEMBL8726189 | 0.69 | MAPT (0.53) | KDM4ERAB9ANPC1MAPTFBP1 | |
| SCHEMBL7371644 | 0.69 | ALDH1A1 (0.47) | FBP1ALDH1A1 | |
| SCHEMBL7367829 | 0.69 | MAPT (0.53) | KDM4ERAB9ANPC1MAPTFBP1 | |
| SCHEMBL7375356 | 0.69 | RAB9A (0.45) | KDM4ERAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL6754408 | 0.68 | MAPT (0.54) | RAB9ANPC1MAPTALDH1A1HPGD | |
| SCHEMBL4610015 | 0.68 | MAPT (0.54) | RAB9ANPC1MAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237929-B1 | 3,5-DISUBSTITUTED PYROCATECHOL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-06-02 | — | — | EP | disclosed |
| EP-0237929-A1 | 3,5-Disubstituted pyrocatechol derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1987-09-23 | — | — | EP | disclosed |