Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | PDE2A | O00408 | 3/20 | 0.47 |
| ▸ | PDE5A | O76074 | 3/20 | 0.47 |
| ▸ | PDE11A | Q9HCR9 | 3/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | PRKCG | P05129 | 1/20 | 0.46 |
| ▸ | PRKCB | P05771 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | PRKCA | P17252 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7375818 | 0.92 | POLB (0.45) | POLBMAPK1HTTTSHRHSD17B10 | |
| SCHEMBL7370741 | 0.88 | MAPT (0.54) | MAPK1HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL7372230 | 0.86 | FYN (0.50) | POLBMAPK1HSD17B10KDM4EALDH1A1 | |
| SCHEMBL7374247 | 0.85 | ERN1 (0.46) | PDE2APDE5APDE11APDE10APDE4A | |
| SCHEMBL7373609 | 0.83 | MAPT (0.44) | MAPK1HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL7368774 | 0.83 | P2RX7 (0.50) | POLBMAPK1HTTALDH1A1PDE2A | |
| SCHEMBL7369440 | 0.83 | CYP11B1 (0.45) | POLBMAPK1HTTPDE2APDE5A | |
| SCHEMBL7370764 | 0.83 | KDM4E (0.48) | POLBMAPK1HSD17B10KDM4EPDGFRB | |
| SCHEMBL7367019 | 0.83 | PDE2A (0.43) | MAPK1HSD17B10KDM4EPDE2APDE5A | |
| SCHEMBL7365766 | 0.82 | APLNR (0.45) | POLBALDH1A1PDGFRBPDE2APDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4822805-A | ANTIINFLAMMATORY AGENTS, CARDIOTONIC AGENTS, ANTIPLATELET AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-18 | — | — | US | disclosed |
| EP-0257897-A1 | Imidazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-02 | — | — | EP | disclosed |