Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | PDE2A | O00408 | 3/20 | 0.43 |
| ▸ | PDE5A | O76074 | 3/20 | 0.43 |
| ▸ | PDE11A | Q9HCR9 | 3/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KLK3 | P07288 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7372230 | 0.91 | FYN (0.50) | MAPTGLAKDM4EPDE2APDE5A | |
| SCHEMBL7370741 | 0.91 | MAPT (0.54) | MAPTGLAKDM4EPDE2APDE5A | |
| SCHEMBL7370295 | 0.83 | POLB (0.52) | KDM4EPDE2APDE5APDE11APDE10A | |
| SCHEMBL7367019 | 0.83 | PDE2A (0.43) | MAPTGLAKDM4EPDE2APDE5A | |
| SCHEMBL7368881 | 0.82 | CYP11B2 (0.51) | MAPTGLAKDM4ENPC1RAB9A | |
| SCHEMBL7370764 | 0.81 | KDM4E (0.48) | MAPTGLAKDM4EPDE2APDE5A | |
| SCHEMBL7374247 | 0.81 | ERN1 (0.46) | PDE2APDE5APDE11APDE10APDE4A | |
| SCHEMBL7365766 | 0.81 | APLNR (0.45) | MAPTPDE2APDE5APDE11APDE10A | |
| SCHEMBL7372635 | 0.81 | CYP11B2 (0.52) | GLAKDM4EPDE2APDE5APDE11A | |
| SCHEMBL10567162 | 0.80 | CYP11B2 (0.45) | KDM4EPDE2APDE5APDE11APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4822805-A | ANTIINFLAMMATORY AGENTS, CARDIOTONIC AGENTS, ANTIPLATELET AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-18 | — | — | US | disclosed |
| CN-87105680-A | Imidazolium compounds and preparation method thereof and comprise the pharmaceutical composition of this compound | — | 1988-04-27 | — | — | CN | disclosed |
| EP-0257897-A1 | Imidazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-02 | — | — | EP | disclosed |