Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 14/20 | 0.56 |
| ▸ | MMP3 | P08254 | 13/20 | 0.56 |
| ▸ | MMP9 | P14780 | 9/20 | 0.56 |
| ▸ | MMP13 | P45452 | 7/20 | 0.56 |
| ▸ | MMP7 | P09237 | 7/20 | 0.56 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.49 |
| ▸ | MMP8 | P22894 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 3/20 | 0.47 |
| ▸ | MMP14 | P50281 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7765009 | 0.91 | MMP1 (0.58) | MMP1MMP3MMP9MMP13MMP7 | |
| SCHEMBL3914496 | 0.90 | MMP1 (0.58) | MMP1MMP3MMP9MMP13MMP7 | |
| SCHEMBL5635689 | 0.89 | MMP9 (0.52) | MMP1MMP3MMP9MMP13MMP7 | |
| SCHEMBL1617124 | 0.82 | PKM (0.55) | MMP1MMP3MMP9MMP13MMP7 | |
| SCHEMBL27488462 | 0.81 | MMP9 (0.56) | MMP1MMP3MMP9MMP13MMP7 | |
| SCHEMBL14878432 | 0.78 | SCN9A (0.47) | MMP1MMP3MMP9MMP13MMP7 | |
| SCHEMBL6269395 | 0.77 | MMP1 (0.76) | MMP1MMP3MMP9MMP13MMP7 | |
| SCHEMBL6344488 | 0.76 | MMP1 (0.74) | MMP1MMP3MMP9MMP13MMP7 | |
| SCHEMBL6344485 | 0.76 | MMP1 (0.74) | MMP1MMP3MMP9MMP13MMP7 | |
| Hydrochloric Acid SCHEMBL6863986 | 0.76 | MMP1 (0.74) | MMP1MMP3MMP9MMP13MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874830-A1 | METALLOPROTEINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PHARMACEUTICAL USES, AND METHODS AND INTERMEDIATES USEFUL FOR THEIR PREPARATION | AGOURON PHARMACEUTICALS, INC. (US) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997020824-A1 | METALLOPROTEINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PHARMACEUTICAL USES, AND METHODS AND INTERMEDIATES USEFUL FOR THEIR PREPARATION | AGOURON PHARMACEUTICALS, INC. (US) | 1997-06-12 | — | — | WO | disclosed |