Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | PDE2A | O00408 | 1/20 | 0.51 |
| ▸ | TEK | Q02763 | 10/20 | 0.50 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | GCGR | P47871 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370913 | 0.85 | NPY5R (0.57) | NPC1RAB9APDE2ASMPD3NPY5R | |
| SCHEMBL7365842 | 0.84 | TGFBR1 (0.70) | NPC1RAB9APDE2ATEKTGFBR1 | |
| SCHEMBL7374774 | 0.79 | PDE2A (0.57) | NPC1RAB9APDE2ATEKSMPD3 | |
| SCHEMBL7374799 | 0.77 | SMPD3 (0.56) | NPC1SMPD3TGFBR1MAPK13MAPK12 | |
| SCHEMBL4133106 | 0.77 | NPC1 (0.64) | NPC1RAB9A | |
| SCHEMBL7365692 | 0.76 | NPY5R (0.57) | NPC1RAB9ASMPD3NPY5R | |
| SCHEMBL941325 | 0.75 | NOX1 (0.61) | PDE2ATEKSMPD3MAPK13MAPK12 | |
| SCHEMBL20445309 | 0.75 | SMPD3 (0.61) | NPC1RAB9ASMPD3NPY5R | |
| SCHEMBL29363231 | 0.75 | NOX1 (0.61) | PDE2ATEKSMPD3MAPK13MAPK12 | |
| Hydrochloric Acid SCHEMBL23736201 | 0.74 | SMPD3 (0.60) | NPC1RAB9ASMPD3NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4822805-A | ANTIINFLAMMATORY AGENTS, CARDIOTONIC AGENTS, ANTIPLATELET AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-18 | — | — | US | disclosed |
| EP-0257897-A1 | Imidazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-02 | — | — | EP | disclosed |