SCHEMBL7369928

SCHEMBL7369928

NC(c1ccc2ccncc2c1)[C@@]1(NC(=O)OCc2ccccc2)CCNC1=O

nearest known ligand 0.41

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ROCK2 O75116 9/20 0.41
POLB P06746 1/20 0.37
LMNA P02545 1/20 0.36
TP53 P04637 1/20 0.36
GFER P55789 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
CYP3A4 P08684 3/20 0.36
PPIA P62937 1/20 0.36
TSHR P16473 2/20 0.36
MRGPRX4 Q96LA9 1/20 0.36
MAP4K1 Q92918 1/20 0.35
AKT1 P31749 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7367861 0.88 ROCK2 (0.40) ROCK2POLBLMNATP53GFER
SCHEMBL7376594 0.86 ROCK2 (0.42) ROCK2POLBPPIAAKT1
Trifluoroacetic Acid SCHEMBL7376828 0.74 AKT1 (0.33) ROCK2AKT1
SCHEMBL29678933 0.68 CTSL (0.58) CYP3A4TSHR
SCHEMBL7374405 0.68 AKT1 (0.35) ROCK2AKT1
Trifluoroacetic Acid SCHEMBL7376557 0.67 MMP13 (0.33) AKT1
SCHEMBL26833122 0.66 DDB1 (0.44) POLBLMNASMN1; SMN2
SCHEMBL23636091 0.65 KMT2A (0.62) ROCK2LMNASMN1; SMN2TSHRMRGPRX4
SCHEMBL10741489 0.65 CA12 (0.46) POLBLMNASMN1; SMN2TSHR
SCHEMBL10741497 0.65 CA12 (0.46) POLBLMNASMN1; SMN2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1086099-A4 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS AVENTIS PHARM PROD INC (US) 2002-01-02 EP disclosed
EP-0944386-A4 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS AVENTIS PHARM PROD INC (US) 2001-04-11 EP disclosed
EP-1086099-A1 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS Aventis Pharmaceuticals Products Inc. (US) 2001-03-28 EP disclosed
WO-1999062904-A1 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS AVENTIS PHARMACEUTICALS PRODUCTS INC. (US) 1999-12-09 WO disclosed
EP-0944386-A1 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) 1999-09-29 EP disclosed
WO-1998025611-A1 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS RHÔNE-POULENC RORER PHARMACEUTICALS INC. (US) 1998-06-18 WO disclosed