SCHEMBL7367861

SCHEMBL7367861

O=C(N[C@]1(C(Oc2ccccc2)c2ccc3ccncc3c2)CCNC1=O)OCc1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ROCK2 O75116 8/20 0.40
PPIA P62937 1/20 0.37
MRGPRX4 Q96LA9 1/20 0.36
POLB P06746 1/20 0.36
AKT1 P31749 1/20 0.36
IMPDH2 P12268 1/20 0.36
LMNA P02545 1/20 0.35
TP53 P04637 1/20 0.35
GFER P55789 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
CYP3A4 P08684 2/20 0.35
CTSL P07711 2/20 0.35
CTSS P25774 2/20 0.35
CTSK P43235 2/20 0.35
TSHR P16473 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7369928 0.88 ROCK2 (0.41) ROCK2PPIAMRGPRX4POLBAKT1
SCHEMBL7376594 0.86 ROCK2 (0.42) ROCK2PPIAPOLBAKT1IMPDH2
SCHEMBL7422899 0.70 HPGDS (0.34) ROCK2PPIAAKT1
SCHEMBL7369599 0.70 HPGDS (0.34) ROCK2PPIAAKT1
SCHEMBL7373241 0.70 HPGDS (0.34) ROCK2PPIAAKT1
SCHEMBL29678933 0.67 CTSL (0.58) CYP3A4CTSLCTSSCTSKTSHR
SCHEMBL26833122 0.65 DDB1 (0.44) POLBLMNASMN1; SMN2CTSLCTSS
SCHEMBL12058848 0.65 POLB (0.65) ROCK2POLBIMPDH2LMNA
SCHEMBL29679181 0.65 CTSL (0.58) ROCK2CYP3A4CTSLCTSSCTSK
SCHEMBL29679126 0.65 CTSL (0.58) ROCK2CYP3A4CTSLCTSSCTSK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1086099-A4 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS AVENTIS PHARM PROD INC (US) 2002-01-02 EP disclosed
EP-0944386-A4 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS AVENTIS PHARM PROD INC (US) 2001-04-11 EP disclosed
EP-1086099-A1 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS Aventis Pharmaceuticals Products Inc. (US) 2001-03-28 EP disclosed
WO-1999062904-A1 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS AVENTIS PHARMACEUTICALS PRODUCTS INC. (US) 1999-12-09 WO disclosed
EP-0944386-A1 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) 1999-09-29 EP disclosed
WO-1998025611-A1 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS RHÔNE-POULENC RORER PHARMACEUTICALS INC. (US) 1998-06-18 WO disclosed