Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370433 | 0.92 | MAPK1 (0.49) | MAPK1DRD2DRD4DRD3HTR7 | |
| SCHEMBL7369955 | 0.91 | MAPK1 (0.46) | MAPK1DRD2DRD4DRD3HTR7 | |
| SCHEMBL7366955 | 0.85 | HTR6 (0.43) | DRD2DRD3HTR7KDM4EALDH1A1 | |
| SCHEMBL7373267 | 0.81 | HTR1A (0.42) | DRD2DRD3HTR7ACHENPC1 | |
| SCHEMBL8545720 | 0.78 | MAPK1 (0.46) | MAPK1DRD4ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7373095 | 0.77 | MAPK1 (0.46) | MAPK1DRD2DRD4DRD3HTR7 | |
| SCHEMBL7368917 | 0.76 | KDM4E (0.42) | MAPK1DRD2DRD4DRD3HTR7 | |
| SCHEMBL7372515 | 0.75 | MAPK1 (0.44) | MAPK1DRD2DRD4DRD3HTR7 | |
| SCHEMBL8485597 | 0.72 | MAPK1 (0.52) | MAPK1DRD2DRD4DRD3HTR7 | |
| SCHEMBL6031061 | 0.72 | MAPK1 (0.80) | MAPK1DRD2DRD4DRD3HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0706517-B1 | PYRIDAZINONE DERIVATIVES WITH PHARMACEUTICAL ACTIVITY | NISSAN CHEMICAL IND LTD (JP) | 1998-10-21 | — | — | EP | disclosed |
| EP-0706517-A1 | PYRIDAZINONE DERIVATIVES WITH PHARMACEUTICAL ACTIVITY | NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) | 1996-04-17 | — | — | EP | disclosed |
| WO-1995001343-A1 | PYRIDAZINONE DERIVATIVES WITH PHARMACEUTICAL ACTIVITY | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1995-01-12 | — | — | WO | disclosed |