Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 3/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370213 | 0.92 | MAPK1 (0.44) | MAPK1HTR7DRD4DRD2DRD3 | |
| SCHEMBL7369955 | 0.91 | MAPK1 (0.46) | MAPK1HTR7DRD4DRD2POLB | |
| SCHEMBL7366955 | 0.85 | HTR6 (0.43) | HTR7DRD2POLBDRD3KDM4E | |
| SCHEMBL7373267 | 0.85 | HTR1A (0.42) | HTR7DRD2DRD3KMT2A | |
| SCHEMBL7373095 | 0.85 | MAPK1 (0.46) | MAPK1HTR7DRD4UTS2RDRD2 | |
| SCHEMBL7372515 | 0.82 | MAPK1 (0.44) | MAPK1HTR7DRD4UTS2RDRD2 | |
| SCHEMBL8545720 | 0.81 | MAPK1 (0.46) | MAPK1DRD4ALDH1A1KMT2A | |
| SCHEMBL8485597 | 0.81 | MAPK1 (0.52) | MAPK1HTR7DRD4UTS2RDRD2 | |
| SCHEMBL7373473 | 0.76 | HTR7 (0.45) | MAPK1HTR7DRD4UTS2RDRD2 | |
| SCHEMBL9228414 | 0.74 | DRD4 (0.62) | MAPK1HTR7DRD4DRD2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929074-A | VSODILATOR, ANTIALLERGIC AND ANTIPLATELET AGENTS | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 1999-07-27 | — | — | US | disclosed |
| EP-0706517-B1 | PYRIDAZINONE DERIVATIVES WITH PHARMACEUTICAL ACTIVITY | NISSAN CHEMICAL IND LTD (JP) | 1998-10-21 | — | — | EP | disclosed |
| US-5728702-A | BRONCHODILATOR AGENTS, ANTIALLERGENS OR ANTIPLATELET DRUGGS | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 1998-03-17 | — | — | US | disclosed |
| EP-0706517-A1 | PYRIDAZINONE DERIVATIVES WITH PHARMACEUTICAL ACTIVITY | NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) | 1996-04-17 | — | — | EP | disclosed |
| WO-1995001343-A1 | PYRIDAZINONE DERIVATIVES WITH PHARMACEUTICAL ACTIVITY | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1995-01-12 | — | — | WO | disclosed |