Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7373473 | 0.84 | HTR7 (0.45) | KDM4EALDH1A1DRD2DRD4DRD3 | |
| SCHEMBL8489110 | 0.80 | MAPK1 (0.51) | ALDH1A1DRD2DRD4DRD3HTR7 | |
| SCHEMBL7370150 | 0.80 | ACHE (0.41) | KMT2AACHE | |
| SCHEMBL8488822 | 0.77 | DRD2 (0.43) | KDM4EALDH1A1DRD2DRD4DRD3 | |
| SCHEMBL7370213 | 0.76 | MAPK1 (0.44) | KDM4EALDH1A1DRD2DRD4DRD3 | |
| SCHEMBL7367424 | 0.76 | HTR1A (0.42) | DRD2DRD3HTR7 | |
| SCHEMBL7370826 | 0.71 | HTR7 (0.43) | KDM4EALDH1A1DRD2DRD4DRD3 | |
| SCHEMBL7377179 | 0.69 | HTR7 (0.41) | KDM4EALDH1A1DRD2DRD4DRD3 | |
| SCHEMBL7374230 | 0.69 | ALDH1A1 (0.50) | ALDH1A1DRD2DRD4DRD3HTR7 | |
| SCHEMBL7370433 | 0.68 | MAPK1 (0.49) | KDM4EALDH1A1DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0706517-B1 | PYRIDAZINONE DERIVATIVES WITH PHARMACEUTICAL ACTIVITY | NISSAN CHEMICAL IND LTD (JP) | 1998-10-21 | — | — | EP | disclosed |
| EP-0706517-A1 | PYRIDAZINONE DERIVATIVES WITH PHARMACEUTICAL ACTIVITY | NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) | 1996-04-17 | — | — | EP | disclosed |
| WO-1995001343-A1 | PYRIDAZINONE DERIVATIVES WITH PHARMACEUTICAL ACTIVITY | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1995-01-12 | — | — | WO | disclosed |