Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.46 |
| ▸ | PDE2A | O00408 | 5/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.43 |
| ▸ | PDE5A | O76074 | 4/20 | 0.43 |
| ▸ | PDE11A | Q9HCR9 | 4/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
| ▸ | ACLY | P53396 | 3/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7375818 | 0.89 | POLB (0.45) | PDE2APDE10APDE5APDE11APDE4A | |
| SCHEMBL7370295 | 0.85 | POLB (0.52) | PDE2APDE10APDE5APDE11APDE4A | |
| SCHEMBL7372230 | 0.83 | FYN (0.50) | ERN1PDE2APDE10APDE5APDE11A | |
| SCHEMBL7370741 | 0.83 | MAPT (0.54) | PDE2APDE10APDE5APDE11APDE4A | |
| SCHEMBL7366043 | 0.81 | CYP11B1 (0.44) | PDE2APDE10APDE5APDE11APDE4A | |
| SCHEMBL7373609 | 0.81 | MAPT (0.44) | PDE2APDE10APDE5APDE11APDE4A | |
| SCHEMBL7374321 | 0.80 | CYP11B1 (0.43) | PDE2APDE10APDE5APDE11APDE4A | |
| SCHEMBL7376649 | 0.80 | POLB (0.47) | CYP11B2MKNK1MKNK2NPC1RAB9A | |
| SCHEMBL7372122 | 0.79 | CYP11B1 (0.46) | PDE2APDE10APDE5APDE11APDE4A | |
| SCHEMBL7369883 | 0.79 | CYP11B1 (0.46) | PDE2APDE10APDE5APDE11APDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4822805-A | ANTIINFLAMMATORY AGENTS, CARDIOTONIC AGENTS, ANTIPLATELET AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-18 | — | — | US | disclosed |
| EP-0257897-A1 | Imidazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-02 | — | — | EP | disclosed |