Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 2/20 | 0.46 |
| ▸ | FEN1 | P39748 | 2/20 | 0.46 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.46 |
| ▸ | SMURF2 | Q9HAU4 | 1/20 | 0.45 |
| ▸ | SMURF1 | Q9HCE7 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367699 | 0.87 | ERCC1 (0.43) | ERCC1FEN1ERCC4KDM4EMEN1 | |
| SCHEMBL19668565 | 0.81 | KDM4E (0.42) | ERCC1FEN1ERCC4KDM4EPTPN1 | |
| SCHEMBL8135086 | 0.78 | MCL1 (0.41) | ERCC1FEN1ERCC4KDM4EPTPN1 | |
| SCHEMBL7369992 | 0.78 | SMN1; SMN2 (0.42) | KDM4EMEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL30010967 | 0.77 | EDNRA (0.47) | KDM4EMEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL27353038 | 0.76 | MCL1 (0.42) | ERCC1FEN1ERCC4KDM4EPTPN1 | |
| SCHEMBL4076415 | 0.76 | PTPN1 (0.67) | SMURF2SMURF1KDM4EPTPN1MEN1 | |
| SCHEMBL7367693 | 0.75 | KDM4E (0.43) | KDM4EMEN1KMT2AALDH1A1HTT | |
| Ethyl Acetate SCHEMBL27347866 | 0.74 | ALDH1A1 (0.44) | KDM4EMEN1KMT2AALDH1A1HTT | |
| SCHEMBL8119682 | 0.73 | GRIA1 (0.53) | KDM4EMEN1KMT2AMAPK1MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1056837-C | 5-arylisoxazol-4-yl-substituted 2-aminocarboxylic acid compounds | LUNDBECK & CO AS H (DK) | 2000-09-27 | — | — | CN | disclosed |
| EP-0994107-A1 | 5-Arylisoxazol-4-yl-substituted 2-amino carboxylic acid compounds | H. LUNDBECK A/S (DK) | 2000-04-19 | — | — | EP | disclosed |
| CN-1136810-A | 5-arylisoxazol-4-yl-substituted 2-aminocarboxylic acid compounds | LUNDBECK & CO AS H (DK) | 1996-11-27 | — | — | CN | disclosed |
| EP-0726896-A1 | 5-ARYLISOXAZOL-4-YL-SUBSTITUTED 2-AMINO CARBOXYLIC ACID COMPOUNDS | H. LUNDBECK A/S (DK) | 1996-08-21 | — | — | EP | disclosed |
| WO-1995012587-A1 | 5-ARYLISOXAZOL-4-YL-SUBSTITUTED 2-AMINO CARBOXYLIC ACID COMPOUNDS | H. LUNDBECK A/S (DK) | 1995-05-11 | — | — | WO | disclosed |