Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.31 |
| ▸ | BUB1 | O43683 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.30 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19638080 | 0.79 | GPR119 (0.38) | MEN1KMT2ABCHEGPR119BUB1 | |
| SCHEMBL31119448 | 0.76 | GPR119 (0.41) | MEN1KMT2ACTSKBCHEGPR119 | |
| SCHEMBL7023132 | 0.76 | NR1H2 (0.41) | MEN1KMT2ABCHENR1H2 | |
| SCHEMBL7014583 | 0.72 | CA12 (0.42) | MEN1KMT2A | |
| SCHEMBL7528678 | 0.72 | ESR2 (0.40) | MEN1KMT2ABCHEGPR119BUB1 | |
| SCHEMBL11911366 | 0.72 | GPR119 (0.39) | MEN1KMT2ABCHEGPR119NR1H2 | |
| SCHEMBL28581988 | 0.70 | BCHE (0.38) | MEN1KMT2ABCHEGPR119BUB1 | |
| SCHEMBL1018306 | 0.70 | BCHE (0.38) | MEN1KMT2ABCHEGPR119NR1H2 | |
| SCHEMBL12593934 | 0.70 | NR1H2 (0.41) | MEN1KMT2ABCHEGPR119NR1H2 | |
| SCHEMBL20033881 | 0.70 | BCHE (0.38) | MEN1KMT2ABCHEGPR119NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6191145-B1 | ANTICOAGULANTS; ANTIINFLAMMATORY AGENTS | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2001-02-20 | — | — | US | disclosed |
| EP-1028943-A2 | ORALLY-ACTIVE NIPECOTAMIDE GLYCOLAMIDE ESTERS FOR THE TREATMENT OF THROMBOSIS DISORDERS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2000-08-23 | — | — | EP | disclosed |
| US-6066651-A | ANTITHROMBOTIC AGENTS BY VIRTUE OF THEIR ABILITY TO PREVENT PLATELET AGGREGATION | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2000-05-23 | — | — | US | disclosed |
| WO-1999021832-A2 | ORALLY-ACTIVE NIPECOTAMIDE GLYCOLAMIDE ESTERS FOR THE TREATMENT OF THROMBOSIS DISORDERS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 1999-05-06 | — | — | WO | disclosed |