Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 2/20 | 0.50 |
| ▸ | HCRTR1 | O43613 | 9/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 9/20 | 0.40 |
| ▸ | PLAU | P00749 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7371376 | 0.92 | CASP3 (0.50) | CASP3HCRTR1HCRTR2PLAULMNA | |
| SCHEMBL7374254 | 0.92 | CASP3 (0.50) | CASP3HCRTR1HCRTR2PLAULMNA | |
| SCHEMBL7450926 | 0.87 | PLAU (0.51) | HCRTR1HCRTR2PLAULMNAMMP9 | |
| Hydrochloric Acid SCHEMBL7368466 | 0.87 | PLAU (0.51) | HCRTR1HCRTR2PLAULMNAMMP9 | |
| SCHEMBL7380965 | 0.80 | PLAU (0.53) | HCRTR1HCRTR2PLAULMNA | |
| Hydrochloric Acid SCHEMBL6437188 | 0.79 | CASP3 (0.50) | CASP3PLAU | |
| SCHEMBL7365364 | 0.79 | PLAU (0.54) | HCRTR1HCRTR2PLAULMNAKDM4E | |
| Hydrochloric Acid SCHEMBL7368609 | 0.78 | PLAU (0.53) | HCRTR1HCRTR2PLAULMNAKDM4E | |
| Hydrochloric Acid SCHEMBL7366142 | 0.78 | PLAU (0.53) | HCRTR1HCRTR2PLAULMNAKDM4E | |
| SCHEMBL6434558 | 0.78 | CASP3 (0.51) | CASP3PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242120-A2 | COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE | Pfizer Limited (GB) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001049309-A2 | COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE | PFIZER LIMITED (GB) | 2001-07-12 | — | — | WO | disclosed |
| EP-1077945-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-2000005214-A2 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2000-02-03 | — | — | WO | disclosed |