Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 10/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 10/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HPN | P05981 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7365364 | 0.94 | PLAU (0.54) | PLAULMNAHCRTR1HCRTR2RECQL | |
| Hydrochloric Acid SCHEMBL7368609 | 0.93 | PLAU (0.53) | PLAULMNAHCRTR1HCRTR2RECQL | |
| Hydrochloric Acid SCHEMBL7366142 | 0.93 | PLAU (0.53) | PLAULMNAHCRTR1HCRTR2RECQL | |
| SCHEMBL7370379 | 0.91 | PLAU (0.54) | PLAULMNAHCRTR1HCRTR2RECQL | |
| Hydrochloric Acid SCHEMBL7369946 | 0.90 | PLAU (0.54) | PLAULMNAHCRTR1HCRTR2RECQL | |
| Hydrochloric Acid SCHEMBL7369169 | 0.90 | PLAU (0.54) | PLAULMNAHCRTR1HCRTR2RECQL | |
| SCHEMBL7368857 | 0.89 | LMNA (0.45) | PLAULMNAHCRTR1HCRTR2RECQL | |
| SCHEMBL7371376 | 0.88 | CASP3 (0.50) | PLAULMNAHCRTR1HCRTR2RECQL | |
| SCHEMBL7374254 | 0.88 | CASP3 (0.50) | PLAULMNAHCRTR1HCRTR2RECQL | |
| Hydrochloric Acid SCHEMBL7378442 | 0.86 | PLAU (0.54) | PLAULMNAHCRTR1HCRTR2RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077945-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-2000005214-A2 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2000-02-03 | — | — | WO | disclosed |