Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 3/20 | 0.42 |
| ▸ | RXRB | P28702 | 2/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.42 |
| ▸ | BAD | Q92934 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | RARB | P10826 | 4/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ADH5 | P11766 | 2/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | RARG | P13631 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7374384 | 0.85 | RXRA (0.45) | LMNAKDM4EHSD17B10RXRARXRB | |
| SCHEMBL7374419 | 0.83 | LMNA (0.40) | LMNAKDM4EALDH1A1SMN1; SMN2HTT | |
| SCHEMBL7370563 | 0.82 | SRD5A2 (0.49) | KDM4ERXRARXRBRARBMAP4K4 | |
| SCHEMBL7371208 | 0.80 | RXRA (0.44) | LMNARXRARXRBRARBMAP4K4 | |
| SCHEMBL7371306 | 0.77 | KDM5A (0.43) | RXRARXRBRARBMAP4K4ALDH1A1 | |
| SCHEMBL16749653 | 0.75 | RXRA (0.59) | RXRARXRBBCL2L1BADRARB | |
| SCHEMBL22824136 | 0.73 | RXRA (0.57) | RXRARXRBBCL2L1BADRARB | |
| SCHEMBL3641384 | 0.73 | ALDH1A1 (0.53) | LMNAKDM4EHSD17B10RXRARXRB | |
| SCHEMBL2951077 | 0.72 | RXRA (0.55) | RXRARXRBRARBMAP4K4ALDH1A1 | |
| SCHEMBL6252810 | 0.72 | RARB (0.61) | LMNAKDM4EHSD17B10RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994021650-A1 | BORONIC ACID AND ESTER INHIBITORS OF THROMBIN | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-09-29 | — | — | WO | disclosed |