Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 11/20 | 0.44 |
| ▸ | HSD17B2 | P37059 | 10/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7378235 | 0.85 | GPBAR1 (0.45) | HSD17B1HSD17B2ALDH1A1GPBAR1TSHR | |
| SCHEMBL7372957 | 0.83 | ALDH1A1 (0.47) | HSD17B1HSD17B2ALDH1A1GPBAR1SIGMAR1 | |
| SCHEMBL384544 | 0.79 | MAPT (0.46) | ALDH1A1TSHRMAPTSMN1; SMN2 | |
| SCHEMBL3807892 | 0.79 | ALDH1A1 (0.51) | HSD17B1HSD17B2ALDH1A1 | |
| SCHEMBL7408912 | 0.77 | TSHR (0.56) | ALDH1A1TSHRMAPTSMN1; SMN2 | |
| SCHEMBL23367914 | 0.76 | GPBAR1 (0.47) | HSD17B1HSD17B2ALDH1A1GPBAR1 | |
| SCHEMBL7371730 | 0.75 | CRHBP (0.51) | ALDH1A1GPBAR1TSHRMAPTSMN1; SMN2 | |
| SCHEMBL8300884 | 0.74 | CASP6 (0.49) | HSD17B1HSD17B2ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL20041120 | 0.72 | ALDH1A1 (0.59) | HSD17B1HSD17B2ALDH1A1TSHRTP53 | |
| SCHEMBL5981277 | 0.72 | GPBAR1 (0.65) | GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211242-B1 | CARDIOVASCULAR DISORDERS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-04-03 | — | — | US | disclosed |
| EP-0757670-B1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO (JP) | 1999-01-13 | — | — | EP | disclosed |
| EP-0757670-A1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-02-12 | — | — | EP | disclosed |
| WO-1995029152-A1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-11-02 | — | — | WO | disclosed |