Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | EIF4E | P06730 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370855 | 0.86 | NPY5R (0.50) | HTTP2RX7NPY5RKDRMAPT | |
| SCHEMBL7367075 | 0.85 | NPY5R (0.48) | NPY5RMAPTNPC1RAB9AMAPK1 | |
| SCHEMBL7371087 | 0.83 | NPC1 (0.43) | POLBHTTADORA2AKDRMKNK1 | |
| SCHEMBL7372407 | 0.81 | LMNA (0.49) | P2RX7NPY5RNPC1RAB9AALDH1A1 | |
| SCHEMBL7374247 | 0.80 | ERN1 (0.46) | MKNK1MKNK2NPC1RAB9ACYP11B2 | |
| SCHEMBL7375818 | 0.80 | POLB (0.45) | POLBHTTKDRMKNK1MKNK2 | |
| SCHEMBL7372671 | 0.80 | KDM4E (0.46) | MAPTNPC1RAB9AMAPK1ALDH1A1 | |
| SCHEMBL7369586 | 0.80 | ROS1 (0.47) | BCHEMAPK1CYP11B2 | |
| SCHEMBL7370741 | 0.80 | MAPT (0.54) | NPY5RMKNK1MKNK2MAPTNPC1 | |
| SCHEMBL7373609 | 0.78 | MAPT (0.44) | MKNK1MKNK2MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4822805-A | ANTIINFLAMMATORY AGENTS, CARDIOTONIC AGENTS, ANTIPLATELET AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-18 | — | — | US | disclosed |
| EP-0257897-A1 | Imidazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-02 | — | — | EP | disclosed |